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Biomedical Sciences

HOD Profile

Professor Arun Dharmarajan
Professor Arun Dharmarajan
MSc, M.Med. Science, PhD (Uni of Western Australia, Perth, Australia)
Biomedical Sciences
34 Years of experience since highest degree
Intro

Professor Arun Dharmarajan was educated at the University of Western Australia, Perth, Australia (PhD). He did his postdoctoral training at Johns Hopkins University School of Medicine, Baltimore, USA. On completion of his postdoctoral training, he was appointed as an instructor in the department of Gynecology and Obstetrics and subsequently was promoted to Assistant, Associate Professor and Director of Reproductive Endocrinology in the same department. Professor Dharmarajan, moved back to UWA late 1994 having spent 10 years at Johns Hopkins, Baltimore USA. He has been a Professor in the School of Anatomy, Physiology and Human Biology, University of Western Australia, Perth since 2000. He has served in numerous committess both at Johns Hopkins and University of Western Australia. A few to mention are Promotions, GRS, Schlarships and Publication Audit Committee. Currently Professor Dharmarajan is at the School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences at Curtin University, Perth, Australia. The main focus of Professor Dharmarajan’s research is to investigate the role of Secreted Frizzled Protein-4 (SFRP4) and its interaction with Wnt signalling molecules in cancer and specifically cancer stem cells. This protein was discovered by Professor Dharmarajn in collaboration with Professor Bob Fris, University of Bern, Switzerland in early 90s.

Professor Dharmarajan’s research has spanned 35 years in International academia under the areas of Reproduction, Endocrinology, Apoptosis and most recently (over the past 20 years) in Cancer Biology. His work in the fields of Reproduction and Endocrinology have lead him to Editorial Board memberships of top ranking journals in the field including Biology of Reproduction, Endocrinology, Reproductive Biomedicine Online, Molecular and Cellular Reproduction, Molecular and Cellular Endocrinology etc. Professor Dharmarajan’s work in Apoptosis has lead me to Editorial Board membership in the journal Apoptosis. His primary focus areas in the 80s through the 90s was corpus luteum regulation in conjunction with Cellular Death. Then, a look at Angiogenesis with Secreted Frizzled Related Protein-4 (SFRP4) which was published in the American Journal of Pathology. And recently more research on the role of SFRP4 on cancer stem cells, metabolism, metastasis and regulation. Overall my research since the 80s has provided me the opportunity to serve as Editorial board member of over 15 high impact (/>3) international Journals since the very early 90s.

Professor Dharmarajan has published over 177 research articles and supervised more than 120 Hons, MSc and PhD and Postdoctoral Research Fellows. His H-Index is 40.Several of his students have received distinction for their PhDs and pursing their career in Academia. He is also guest editor of a few journals including Cancers (IF 5.3). Professor Dharmarajan has been invited to speak at more than 100 National and International conferences. He is a reviewer for more than 75 International Journals.

Professor Dharmarajan has received funding from Rockefeller Foundation, Lalor Foundation, Raine Medical Foundation, NIH, NHMRC and ARC since 1986. More recently he has been awarded a grant from Ovarian Cancer Foundation, Australia.

During his tenure at Curtin University, he won Curtin Innovation Award (Health Sciences Prize;2016).

Professor Dharmarajan has joined Sri Ramachandra Institute of Higher Education and Research as Head of Biomedical Sciences and Vice Principal of Faculty of Biomedical Sciences, Technology and Research having worked in Australia and USA for 38 years.

Area of Research Expertise

Cancer Biology, Stem Cell Biology, Wnt Signalling, Angiogenesis, Secreted Frizzled Related Protein-4 (SFRP4), Cancer stem Cell, Cancer Cell Metabolism, Molecular Modelling, Reproductive Endocrinology

Membership in Committees

Johns Hopkins University, Baltimore, USA Research Committee (Director of Research), Grants Committee, Faculty Selection, Graduate Students Committee, NIH Study Section panel
University of Western Australia, Perth
Science Faculty Representative, Centre for Cell and Molecular Biology.
• Science Faculty Representative for Curriculum Development of the new Degree “Bachelor of Molecular Biology”
• MBBS Selection Committee
• Member, Board of Studies of Science
• Program co-coordinator, European Language
• Publication Audit Committee
• Scholarship Committee [Biological and Medical Sciences; (Chair)]
• Scholarship Committee, University of Western Australia
• ARC Small Grants Committee [Biological and Medical Sciences; (Chair), , • Internal Research Grants Scheme Working party
• Academic Board Nominee, SIMS project, UWA
• Chair, Stakeholders Reference Group, SIMS project, UWA
• Postgraduate School Board Promotion and Tenure Committee Curtin University, Perth, Australia Promotion and Tenure Committee Research Committee

Projects


NHMRC-Ideas Grant with Dr Mark Agostino (CIB) Optimising the anti-angiogenic activity of the netrin-like domain of sFRP4 through selective integrin targeting
NHMRC-Ideas Grant with Prof Crispin Dass (CIC) Examining the role of PEDF in breast cancer metastasis – possible adjuvant therapy in future for patients
Ovarian Cancer Foundation Grant- With A/Prof Pradeep Tanwar-Uni of Newcastle, NSW (CIB)-Funded AU$566- 3 years (July 1-2019-June 31, 2022) Defining the roles of hormones in the pathogenesis of ovarian cancer
NSW-Cancer Council Grant with A/Prof Pradeep Tanwar-Uni of Newcastle, NSW (CIB) Ovarian steroid hormones regulate the growth and development of Fallopian tube serous intraepithelial neoplastic lesions
PhD students/postdocs (around 120) Total number of PhD students supervised- 26, Postdoctoral Fellows- 20, MSc – 20, BSc Hons- 56

Awards and Recognitions

Several awards since 1986 including Curtin University (Perth, Australia) Innovation award (2016), best publication, and presentation (Oral and Poster)

publications