CEFTE offers comprehensive consultancy testing services for drug
development using laboratory test systems viz. Rats, Mice, Rabbits,
Guinea pigs, cell lines, human lymphocytes and bacterial strains
A. Toxicity /Safety testing B. Efficacy / Pharmacology testing
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Toxicology services includes
- Acute / Single dose toxicity
- MTT and dose findings
- Local toxicity studies- Skin / Eye / Mucous membrane
- Skin sensitization- Guinea pig (GPMT/Buehlar)
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Sub-acute / Sub-chronic toxicity (Repeated Dose 7/14/28/90 day )
- Chronic toxicity - Repeated dose 180 day / one year
- Carcinogenicity
- Reproduction & developmental toxicity
- Fertility, teratology, multi-generation studies
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Genetic Toxicity services (OECD/ ISO 10993-3)
- Bacterial Reverse Mutation Test (AMES)
- In vitro and Invivo Micronucleus test
- In vitro and Invivo Chromosomal aberration test
- Mouse lymphoma assay
- Comet assay
- In Vitro Cytotoxicity (ISO 10993-5)
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Biocompatibility Testing (Medical device)
- Hemocompatibility Testing
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Pharmacokinetics and Toxicokinetics
- Single bolus - oral and intravenous route of administration
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Bio-analytical Assays (Large Molecule)
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Method development, validation and sample analysis as per EMA/FDA
guidelines
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Critical reagent production
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Regular and Cascade immunization against Proteins, Peptides,
Mixture of proteins, Fab fragments, Characterization by ELISA,
Western, IHC, IF and Purification: Protein A/G, Affinity in
Rat/Mouse, Rabbit, Guinea Pig, Goats
- In vivo bioidentity testing of proteins and Peptides
- Anti-sera (polyclonal/monoclonal) - Rat, Mice, Rabbit
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Pharmacological /Disease models
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Well-established and validated in vivo disease / screening models
- Anxiety models (elevated plus maze, hole board,
- Stress induced Hyperthermia
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Cerebral stroke (middle cerebral artery occlusion, 4 vessel
occlusion)
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Depression (Chemical, behavioural CUMS, Stress induced LTD in Rat
Hippocampus)
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Epilepsy (pentylenetetrazole, picrotoxin, strychnine, Bicuculline,
Beta- Carbolines, Guanidine etc)
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Parkinsonism (MPTP model, 6-OHDA Unilateral Intrastriatal Lesion
Model)
- Huntington's disease (3-nitropropionic acid)
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Alzheimer's disease (Scopolamine-induced amnesia, Aβ peptides
infusion)
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Gastric ulcer (Shay model, acetic acid/ ethanol induced, drugs
induced)
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Hepatic diseases (Paracetamol, anti-TB drugs, CCl4, Thioacetamide,
Galactosamine, Azathioprine , concanavillin, Alcoholic /
Non-Alcoholic Steatohepatitis)
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Pharmacological services
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Diabetes (alloxan, streptozotocin, high calorie / diet model,
Dithizone, G-thioglucose genetic models)
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Hyperlipidemia and obesity (triton WR 1339, high fat diet model)
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Hypertension (2K/1C - renovascular, DOCA salt induced, Goldblatt,
etc)
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Cardiac toxicity (Doxorubicin, Anthramycin & Surgical models)
- Myocardial infarction (isoproterenol model)
- Immunology (Cell mediated and humoral mediated)
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Inflammatory models (carrageenan, cotton pellet granuloma etc)
- Rheumatoid arthritis (FCA model)
- Tendonitis (Collagenase & Carrageenan)
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Nootropics (radial arm maze, passive avoidance, transfer latency)
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Pain models (formalin and acetic acid, vincristine, cisplatin,
oxaliplatin, paclitaxel ,etc)
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Stress induced LTD (Long Term Depression) in Hippocampus in rat
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Post Surgical Pain model of mechanical hyperalgesia and allodynia
in rat
- Cancer Xenograft model