AERB Accredited Biodosimetry Lab ICMR centre for Advanced Research in Environmental Health: Air Pollution WHO Collaborating Centre for Environmental Health

ATOMIC ENERGY REGULATORY BOARD (AERB) ACCREDITED BIODOSIMETRY LABORATORY
(HUMAN GENETICS DEPARTMENT)

AIM OF THE CENTRE

To focus on harmonization of methodology, quality assurance and inter-comparison exercises related to radiation biodosimetry
To conduct periodic awareness programs in order to provide basic information on radiation protection to those without formal radiation medicine expertise
To update the knowledge on biodosimetry on a periodic basis in order to be up to date with current international / national standards recommended for biodosimetry
To participate in biodosimetry during national / international nuclear/ radiological emergencies for management of exposed individuals

S.NO	Project title	Funding Agency	Year	Status
1	Biological Dosimetry Preparedness - Validation on the measurement of translocation frequency by chromosome painting and G-banding for dosimetry	AERB	2002	Completed
2	Study on the genetic variation of HLA-G alleles in couples with unexplained recurrent spontaneous abortion in south India.	DST	2006	Completed
3	Genomic instability in Bystander Human Cells and their Progeny exposed to Ionizing Radiation using 3-D cultures	DST	2007	Completed
4	Cytogenetics of idiopathic mental retardation.	ICMR	2010	Completed
5	Inter laboratory comparison of radiation dose response calibration curve using dicentric assay”.	ICMR	2010	Completed
6	Standardization and establishment of g-H2AX assay for triage biodosimetry	LSRB-DRDO	2013	Completed
7	Biological effects of low dose ionizing radiations received during diagnostic radiological procedures.	SERB-DST	2013	Completed
8	Biological effects of low dose alpha particle radiation exposure to blood lymphocytes for biodosimetry.	AERB	2014	Ongoing
9	Standardization and testing of Premature Chromosome Condensation (PCC) assay for radiation triage and dose estimation.	IGCAR-DAE	2017	Ongoing

Publications:

Venkateswarlu Raavi, J. Surendran,K. Karthik, Solomon F. D. Paul, K. Thayalan, J. Arunakaran and P. Venkatachalam (2018), Measurement of γ-H2AX foci, miRNA-101,and gene expression as a means to quantify radiation-absorbed dose in cancer patients who had undergone radiotherapy, Radiation and Environmental Biophysics (DOI 10.1007/s00411-018-0767-0)
Bhavani M, K. Thyalan, Srinivasan and Venkatachalam P. (2018) A comparison of estimates of doses to radiotherapy patients obtained with the dicentric chromosome analysis and the γ-H2AX assay: Relevance to radiation triage. Applied Radiation and Isotopes., 131:1-7.
Venkateswarlu Raavi, Tamizh Selvan G, Bhavani M, Arun Kumar, Amit Alok, Karthik. K, Namita Kalra, Vijayalakshmi, Solomon F.D Paul, Chaudhury N. K and Venkatachalam (2016). P Mean frequency and relative fluorescence intensity measurement of g-H2AX foci dose response in PBL exposed to g-irradiation - an inter and intra laboratory comparison and its relevance for radiation triage. Cytometry -Part-A 85A:1138-1146.
D. Bakkiam, M.Bhavani, A. ArulAnanthaKumar, Swetha Sonwani, P. Venkatachalam, K.Sivasubramanian, B.Venkatraman (2015) Dicentric assay: Inter-laboratory comparison in Indian laboratories for routine and triage applications. Applied Radiation and Isotopes 99:77-85
Tamizh Selvan G, Chaudhury, N.K and Venkatachalam P. (2015) Comparison of results of the manual and automated scoring of micronucleus frequencies in 60Co-irradiated peripheral blood lymphocytes for triage dosimetry. Applied Radiation and Isotopes 97:70-77.
Bhavani M, Tamizh Selvan G, Vijayalakshmi J, Harpreet Kaur J.S. Adihari, Chaudhury, N.K and Venkatachalam P. (2014) Dicentric chromosome aberration analysis using Giemsa and centromere specific fluorescence in-situ hybridization for biological dosimetry: An inter- and intra-laboratory comparison in Indian laboratories. Applied Radiation and Isotopes 94:85-90

Activities:

Public Awareness Programme on Nuclear Energy IARP (Kalpakkam Chapter) & Sri Ramachandra Institute of Higher Education & Research (DU)

Radiation Safety Awareness Programme IGCAR Kalpakkam & Sri Ramachandra Institute of Higher Education & Research (DU)

Biodosimetry Standerd Operating Protocol (SOP) Manual

Provide biodoimsetry service to the regulatory requirement and to participate in biodosimetry during national / international nuclear/ radiological emergencies for management of exposed individuals.

Consultancy/ Services

Provide biodoimsetry service to the regulatory requirement and to participate in biodosimetry during national / international nuclear/ radiological emergencies for management of exposed individuals