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044 2476 8402 Ext: 379 / 475
Hospital Number
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Doctor Profile - Dr. S. Thanikchalam

Chairman & Director CCC, Professor Emeritus
Dr. S. Thanikchalam

Education:

MBBS, MD ,DM

Area(s) of Specialization:

Clinical Cardiology, Preventive Cardiology, Non-Invasive Cardiology, Epidemiological Studies, Clinical Trials & Basic Research on Herbal Medicine

For Appointment, Call:

044-24766991/45928631

Publications:

  • Results of Total Correction of Tetralogy of Fallot in Twenty-One Cases, JAPI, Vol18, Page nos 585 – 589, 1970 S.C.  Munsi, S. John, T. M. Joseph, D. W. Thomas, B. S. Bhati, I. P. Sukumar, S.  Krishnaswami, J. D. McArthur, S. Thanikachalam & G Cherian
  • Selective Left Atrial Cine Angiography in the recognition of Atrial Thrombus, JAPI, vol. 19, page nos 491 – 494, 1971 G. Cherian, S. C. Munsi, S. Krishnaswami, J. B. McArthur, S. Thanikachalam, P. Sukumar, CJohnson, & S. John
  • Congenital absence of the left pericardium, JAPI, Vol 19. page nos 495 – 497, 1971 S. Thanikachalam, J. D. McArthur, & George Cherian
  • Selective Cine Coronary Arteriography, JAPI, vol19, page nos 759-764, 1971 George Cherian, Susil Cmunsi, J.D. McArthur, I. P. Sukumar, S. Krishnaswami & S. Thanikachalam
  • Right Atrial Thrombus following the closure of Atrial Septal Defect, IHJ, Vol. 26, No 1, page nos. 44-46, 1971 S. Thanikachalam, C. P. Nandakumar, G. Cherian, S. John & S Krishnaswami Lymphatic Drainage of the Heart Muscle and pericardial sac in the Dog, IHJ, Vol. 30, No 5, page nos 287- 292, 1976 S Thanikachalam, P. C. Rajaram, A. Namachivayam, Delangovan, T. R. Viswaanathan & C. Lakshmikanthan.
  • Sub-clinical Diabetic Cardiomyopathy – Assessment by systolic time Intervals, JAPI, Vol. 29, page nos 267 – 272, Pril 1981, S. Thanikachalam, C. Lakshmikanthan, Mohan Viswanathan, R. Alagesan, D Elangovan, A Ramachandran & M Viswanathan
  • M-Mode and Two-Dimensional Echocardiographic features of atrial myxoma, IHJ Vol. 34, No 6, page nos 396-399, 1982 C Lakshmikanthan, R Alagesan, B S Ayyappan, A Tajmul Hussain, S Thanikachalam A Sankaran & D Vaidyanathan
  • Right Ventricular Volume estimation by single plane method – Invitro Cas Study, IHJ, Vol35no 4, page nos218-223,1983S Thanikachalam, G Ravindran, G Jayaraman, T R Vishwanathan, D Elangovan, S Ranjan, C Lakshmikandan & P C Rajaram
  • Color Doppler in Obstructive Valvular Disease, Journal of Echocardiography, Vol10,112 -114, 1988, A review article. Natesan G Pandian, S Thanikachalam, D Elangovan
  • Color Doppler in Regurgitant Lesions, Journal of Echocardiography – 1989, A review article. Natesan G Pandian, S. Thanikachalam, D Elangovan
  • The experience of Mitral balloon valvotomy – Fourth Annual Conference of The Indian College of Cardiology-13th –15th June 1997, Hyderabad.
  • Coronary Angiographic Profile in Diabetics Versus Nondiabetics. Research Society for the Study of Diabetes in India, Madras.12th – 14th December 1997
  • A Case of ball valve thrombus, Echocardiography, A Jrnl of CV Ultrasound & Allied Tech , Vol 16, no 2 page Nos 143-145, 1999 S Thanikachalam, G Sengottuvel, Susan George, M Sampath Kumar, R V Shivakumar, K R Balakrishnan, & J S N Murthy case of Ball Valve Thrombus - Echocardiography – A Jrnl.of CV Ultrasound & Allied Tech. 1999: 16:2.
  • Periodontitis as a Risk Factor for Coronary Heart Disease, A case controlled study. Journal of Clinical periodontology – April-2000, S Thanikachalam, India
  • Article published in the International Journal – the Lancet – “Thrombin – specific anticoagulation with Bivalirudin V/s Heparin in patients receiving fibrinolytic Therapy for acute myocardial infarction”: The Hero- 2 Randomized Trial – December 2001 – S Thanikachalam, India
  • Incidence and risk factors of Asymptomatic First Dose Hypertension with Angiotensin Converting Enzyme Inhibitors in Chronic Heart Failure due to Systolic Dysfunction – Indian Heart Journal, Official publication of The Cardiological Society of India: ORIGINAL ARTICLE – Sadagopan Thanikachalam – March –April 2003 Volume 55, no 2.
  • Is it time redefine the Blood Pressure target for the treatment of Hypertension?-Medicographia-Vol 25,  No.3, 2003, pages – 243 – S Thanikachalam  India
  • The Molecular Aspects of Atherosclerosis, Journal of the atherosclerosis of Physicians of India, Volume 12, pages-153-Feb-2002, S Thanikachalam, India
  • Vascular Endothelium Dysfunction Seeing an Elephant, Journal of the Atherosclerosis of Physician of India, January 2005, S Thanikachalam, India
  • The plain radiographic anticipation of the adequacy of left ventricular size in patients with tetralogy of fallot by studying the level of diaphragmatic domes a new sign.A catheter correlated study of Hundred patients, IJRI,15:1, February 2005, S.Thanikachalam, PC Rajaram, Lakshmikanthan, S Vaidyanathan, N Subramanian
  • Trans-Radial Coronary Angioplasty In Indian Patients – Single Operators Experience, 1st Asian Interventional Cardiovascular Therapeutics, Singapore, 4-6 August 2005
  • Vascular Anatomic Challenges Encountered During Transradial Approach For Coronary Diagnosis And Intervention. 1st Asian Interventional Cardiovascular Therapeutics, Singapore, 4-6 August 2005
  • Ideal Hardware For Selective Coronary Cannulation Using Transradial Approach, 1st Asian Interventional Cardiovascular Therapeutics, Singapore, 4-6 August 2005
  • S. Thanikachalam, Sengottuvelu Gunasekaran, Jain TKallarakkal, Percutaneous Transluminal Coronary Angioplasty by Right Transradial Approach in a Patient with Arteria Lusoria Indian Heart J 2006; 58(4):365-367
  • Thanikachalam et al (2012). Polyphenols in madhumega Cho ora Nam, a Siddha medicine, ameliorates carbohydrate metabolism and oxidative stress in type II diabetic rats. Journal of Ethnopharmacology, 2012, Volume: 142, 331–336
  • Thanikachalam et al (2012). Prevalence of vascular stiffness, a marker of future vascular events in age-matched population in normal population versus hypertension population and diabetic population Circ: 2012, 125, 73-74.
  • Thanikachalam et al (2012). Prevalence of risk factors for coronary artery disease in the middle-income group in South Indian population, Circ: 2012, 125, 7374.
  • Thanikachalam et al (2011). A Comprehensive study on a polyherbal Siddha Compound on Plasma Glucose and Serum Lipids in South Indian Population. Planta Medica, Journal of Medicinal Plant and Natural Product Research, March 2011:77(5):553
  • Thanikachalam et al (2014). Population Study of Urban, Rural and Semiurban Regions for the Detection of Endovascular Disease and Prevalence of Risk Factors and Holistic Intervention Study (PURSE-HIS): Rationale, Study Design and Baseline Characteristics. Accepted in The Global Heart Journal
  • Thanikachalam et al. (2014). Efficacy and Safety Profile of Siddha Compound Madhumega Choornam (MMC) in Type II Diabetic Patients. International Journal for Pharmaceutical Research Scholars, 3(1), 322-329
  • Thanikachalam et al (2014). Venthamarai Chooranam, a Siddha medicine, alleviates hypertension via AT1R and eNOS signaling pathway in renovascular hypertensive rats American. Accepted in Experimental Biology and Medicine
  • Thanikachalam, S. Harivanzan, V. Ramasamy, S. McEniery, C.M. Impact of urban versus rural environment on central blood pressure, aortic stiffness and wave reflections: The PURSE HIS study Artery Research vol. 5 issue 4 December 2011. P. 143-144. DOI: 10.1016/j.artres.2011.10.223. ISSN: 1872-9312.
  • Thanikachalam, M. Bai, S. Harivanzan, V. Shoben, A. Baliga, R.R. Thanikachalam, S. Gender-Specific Plasma Triglyceride/High-Density Lipoprotein Cholesterol Concentration Ratio Levels to identify Insulin Resistance and Associated Cardio-Metabolic Risk Factors in a South Asian Population. Canadian Journal of Cardiology vol. 29 issue 10 October 2013. P. S319-S320 DOI: 10.1016/j.cjca.2013.07.537.ISSN:0828-282X.
  • Principal Components Analysis in a South Asian Population: Cardiovascular Risk Variable Clustering and Obesity AHA Scientific Sessions (Submitted) – 2013

PURSE-HIS Study Publications

  • S. Bai, I. Agustsson, V. Harivanzan, L. Krakoff, and S. Thanikachalam. Age-Dependent Impact of Obesity on Aortic Stiffness Circulation. 2013;128:A16679
  • V. Harivanzan, R. Baliga, W.T. Abraham, S. Thanikachalam. Geographical Location and Gender are Predictors of Elevated High-Sensitive C-Reactive Protein (hsCRP) Levels and the Levels  Strongly Correlate with Metabolic Syndrome (MetS) in a South Asian Population. Arteriosclerosis, Thrombosis, and Vascular Biology 2013;33: A200
  • S. Bai, V. Harivanzan, R. Baliga, W.T. Abraham, S. Thanikachalam. Obesity Is An Independent Predictor Of Arterial Stiffness.  Hypertension 2013; 62: A412
  • S. Bai, A. Shoben, V. Harivanzan, R.R. Baliga, S. Thanikachalam, Gender-Specific Plasma Triglyceride/High-Density Lipoprotein Cholesterol Concentration Ratio Levels to Identify Insulin Resistance and Associated Cardio-Metabolic Risk Factors in a South Asian Population. Canadian Journal of Cardiology 2013; 29: 10, S319-S320.
  • A. Must, M. Begum, V. Hivaarnzan, K. Chui, V. Chomitz, O. Bermudez, S. Thanikachalam. The components of metabolic syndrome in relation to weight status in South Indians.  FASEB J April 9, 2013, 27:1055.15
  • K.K.H. Chui, K. Mahalakshmi, V. Harivanzan, A. Must, O. Bermudez, V. Chomitz, S. Thanikachalam. Association between stressful live events and alcohol consumption among South Indians: findings of a population-based cross-sectional survey.  FASEB J April 9, 2013, 27:845.3
  • V. R. Chomitz, S. SPrabhu, S. Thanikachalam, V. Harivanza, K.K.H. Chui, A. Must, O. Bermudez, Physical activity and sedentary behavior in South Indian adults: Urbanicity, gender, and obesity.  FASEB J April 9, 2013, 27:1055.27
     

Research:

Clinical Research

  • Freedom Trial – TDE PH 304
    Global Multicenter trial for newer treatment modalities in PPH. Freedom UT – 15C Studies    (TDE-PH-302 and TDE – PH-304) conducted united Therapeutics
  • OASIS-5
    An International Randomized Double-Blind Study evaluating the efficacy and safety of fondaparinux versus enoxaparin in the acute treatment of unstable angina / non-ST- Segment elevation MI acute coronary syndromes.
  • OASIS-6
    An International Randomized Study evaluating the efficacy and safety of fondaparinux sodium versus control therapy (And glucose – insulin –potassium infusions versus control) in a broad range of patients with ST-segment elevation acute myocardial infarction.
  • Create Study
    A clinical trial of Reviparin & Metabolic modulation in Acute MI Treatment evaluation A large, simple trial of 7-day treatment with low molecular weight heparin versus Placebo and acute treatment with GIK versus control in patients with suspected acute MI.
  • Hero-2 Study
    An open prospectively Randomized comparison of Hirulog Versus Heparin in patients Receiving Aspirin and Thrombolysis (Streptokinase for the Treatment of Acute Myocardial Infarction (HERO -2)
  • Trust – 402
    “A 12-Week, Multi-Centre, Randomized, Double-Blind, Placebo-Controlled trial of the Safety and Efficacy of Intravenous Remodulin in patients in India with Pulmonary Arterial Hypertension (PAH)” Protocol RIV-PH- 402,403,404, and 405.
  • TDE-PH- 304
    Continuation arm of TDE-PH 302 which is a clinical trail phase III in patients with primary pulmonary hypertension.
  • TRUST STUDY - 403
    It is the continuation of arm of IV Treprostinil in patients with PPH (Phase IV)
  • TROPONIN – T
    This is a non-International study in patients with ACS. Where single and longitudinal blood draw is taken in patients with ACS. In study A & B no fresh patients are being recruited, Only patient who were enrolled in similar study previously are being given treatment in the continuation phase
  • THE BALANCE STUDY
    Treatment of Hyponatremia Based on Lixivaptan in NYHA Class III/IV Cardiac Patient Evaluation.

BASIC RESEARCH

  • Since diabetes plays a significant role for the increased incidence of coronary artery disease and acute coronary syndrome the following studies are undertaken.
  • To study efficacy and safety of Alternate medicine for diabetes mellitus and hypertension which are the two primary risk factors for coronary artery disease.
  • Preclinical evaluation of Madhumega choornam (MMC) to control blood sugar in type 2 diabetes both in-vivo & in-vitro study.
  • Preclinical evaluation of Venthamarai choir AM (VMC) to control blood sugar in type 2 diabetes both in-vivo & in-vitro study.
  • A clinical trial of MMC on randomly selected type 2 diabetes with moderate elevation of blood sugar.
  • Study to be started for comparative evaluation of Metformin and MMC in a double-blind randomized design.

EPIDEMIOLOGICAL RESEARCH
Purse His Study:
“Population Study of Urban, Rural and Semi-urban regions to study the prevalence of risk factors conducive to premature vascular disease and detection of both occult and overt Endovascular disease to intervene in a Holistic manner”. (2007 to till date)
Phase I – 2007 to 2011
Phase II – 2012 – 2015
Phase III – 2015 – March 2017

Awards and Honours:

  • Gold Medal in MD General Medicine
  • National Award by MCI - Dr. B. C. Roy  National Award under Eminent Medical Teacher category - 2003

Other Consultants in Cardiac Care Centre

Cardiac Care Centre

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